Compare pain relief medications including NSAIDs, opioids, and nerve pain treatments. Find safe and effective options for acute and chronic pain management.
Click any medication to view full details, pricing, side effects, and comparisons.
Pain • Inflammation
Pain • Inflammation
Moderate to severe pain
Nerve pain • Seizures
Generic: pregabalin
Nerve pain • Fibromyalgia
Arthritis • Pain
Generic: acetaminophen
Pain relief • Fever reduction
Pain • Fever
Pain relief • Fever reduction
Pain relief • Fever reduction
Pain • Heart attack prevention
Muscle spasms
Pain relief • Fever reduction
Seizures • Nerve pain
Arthritis • Pain
Mild to moderate pain • Cough
Muscle spasms
Depression • Anxiety
Pain relief • Fever reduction
Severe pain
Generic: acetaminophen
Pain relief • Fever reduction
Generic: acetaminophen
Pain relief • Fever reduction
Generic: acetaminophen
Pain relief • Fever reduction
Generic: ibuprofen
Pain relief • Fever reduction
Pain relief • Fever reduction
Pain relief • Fever reduction
Generic: naproxen
Pain relief • Fever reduction
Generic: diclofenac
Pain relief • Fever reduction
Generic: diphenhydramine / naproxen
Pain relief • Fever reduction
Pain relief • Fever reduction
See which medication is right for you with our side-by-side comparison tool.
Compare Two Drugs →Acetaminophen (Tylenol) is generally considered safest for most people when used as directed. NSAIDs like ibuprofen are effective but can affect the stomach and kidneys.
Both are NSAIDs but naproxen lasts longer (8-12 hours vs 4-6 hours for ibuprofen). Naproxen may be better for chronic pain while ibuprofen works faster for acute pain.
Opioids carry a risk of dependence and addiction. They are typically reserved for severe pain when other treatments have failed, and should be used under close medical supervision.